Early Steps of Protein Disaggregation by Hsp70 Chaperone and Class B J-Domain Proteins are Shaped by Hsp110
During stress, protein homeostasis is perturbed by protein misfolding and aggregation. Accumulation of protein aggregates disrupts cellular functions and contributes to ageing and is a hallmark of many neurodegenerative diseases (Hartl et al, 2011; …